Evaluation of the anticonvulsant properties of flurbiprofen in pilocarpine-induced convulsions in mice

Background and objective: Flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), possesses non-selective COX inhibition properties. Some NSAIDs exhibit anticonvulsant effects provide analgesic benefits for seizure patients. This study aimed to assess the potential action of flurbiprofen in mice. Methods: Twenty-five mature male mice were divided into five groups study. To prevent peripheral cholinergic activation, each group injected intraperitoneally with atropine sulfate (1 mg/kg) subcutaneously one hour after dosing. Seizures induced ten minutes later using an intraperitoneal injection 300 mg/kg pilocarpine. Following pilocarpine injection, animals monitored 1 hour. Seizure severity was assessed Racine scale. Results: Oral administration at doses 0, 10, 20, 40 resulted significant decrease convulsion onset substantial reduction duration compared control group. Flurbiprofen 20 inhibited scores pilocarpine-injected dose-dependent manner. A high dose (40 significantly reduced convulsions, delayed onset, decreased (p <0.05). Conclusions: exhibits activity. Further studies are necessary determine primary mechanism action.